Discovery of the first characterized embryo-secreted enabler of and biomarker for viable pregnancy
- Mammalian embryos secrete PreImplantation Factor (PIF)
- PIF plays a key role in the implantation and development of the embryo
- Embryos that do not secrete PIF do not implant
Study of the altered immune state during pregnancy
- Modulation of immunity and inflammation
- Induction of embryonal differentiation and growth
- Neuronal development and protection
Translation into a commercially attractive and execution-ready development pipeline
- Invaluable direction and research contributions of world-leading domain experts
- Synthetic analogue (sPIF) and formulated drug product developed
- Manufacturing and stability established under cGMP (current good manufacturing practices)
- Phase 1 study in an auto-immune disorder successfully completed
- Promising preclinical efficacy in various valuable disease targets
- NIH funding for ongoing long-term toxicology studies as prelude to phase 1b/2 clinical trials
- Collaborations with renowned academic institutions in US, Europe and other geographies
- Significant US government grants and angel financing secured